The pleiotropic benefits of statins

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August undefined, 2024

Webb20 dec. 2024 · As statin use expanded, novel biochemical and clinical benefits were discovered, leading to the development of the pleiotropic model that proposes multiple mechanisms for positive effect, both cholesterol dependent and independent. 2 Branching off cholesterol studies, downstream inhibition of isoprenoid intermediate formation was … Webb6 jan. 2024 · The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol …

Impact of Previous Stroke on Short-Term Myocardial Reinfarction …

WebbHowever, it is not clear that the purported effectiveness of statins in neurodegenerative disorders is directly related to cholesterol-lowering effects of these agents; rather, the pleiotropic functions of statins likely play critical roles. Moreover, it is becoming more apparent with… Visualizza altro Webb1 maj 2024 · The so-called pleiotropic effects are mediated by the reduction of isoprenoids, such as farnesyl-pyrophosphate and geranylgeranyl-pyrophosphate, necessary for the activation of small GTPases like Rho and Ras proteins (Fig. 1A).Statins diversely inhibit RhoA and Rac1 prenylation, modulating endothelial nitric oxide (NO) synthase … grand trail 2023

Statin - Wikipedia

Webb1 okt. 2012 · In recent years, however, a number of additional non-lipid-lowering, or ‘pleiotropic’, effects of statins have been suggested to contribute to their efficacy in … Webb26 okt. 2024 · Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are amongst the most prescribed medications worldwide. Most statins work as a … WebbThe pleiotropic benefits of statins may result from their impact on vascular inflammation. The molecular process underlying this phenomenon is not fully elucidated. Here, RNA … grand traditions fallbrook

Statins Show Promise Against Progression of Liver Disease

Focus on Statins: Lipid-Lowering Mechanisms and Beyond

WebbDespite the progressions in COVID-19 understanding, the optimization of patient-specific therapies remains a challenge. Statins, the most widely prescribed lipid-lowering drugs, … WebbPertaining to the endocrine system the benefits of statins can extend to patients with the polycystic ovarian syndrome and thyroid disease. However, there is also increasing … chinese scholar tree for saleWebb1 okt. 2014 · Recent experimental and clinical evidence indicates that some of the cholesterol-independent or "pleiotropic" effects of statins involve improving or restoring endothelial function, enhancing the stability of atherosclerotic plaques, and decreasing oxidative stress and vascular inflammation. 1,280 PDF grand trail canigo

"Webb7 mars 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis Main. Atherosclerosis is a lipoprotein-driven, inflammatory process underlying heart attack and stroke and is … " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

Pleiotropic effects of statins - PMC - National Center for ...

Webb3 okt. 2024 · ObjectiveTo conduct risk assessment and assess the choice of statins ... with no difference between urban and rural areas. 6 Given the burden of CVD and lipid-lowering benefits of statins, ... cholesterol is present in 25% to 30% of urban and 15% to 20% rural subjects. 7 Statins have lipid lowering and number of pleiotropic ... WebbInhibition of protein prenylation for proteins such as RhoA (and subsequent inhibition of Rho-associated protein kinase) may be involved, at least partially, in the improvement of endothelial function, modulation of immune function, and other pleiotropic cardiovascular benefits of statins, as well as in the fact that a number of other drugs that lower LDL …

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Webb17 sep. 2015 · “Pleiotropic" effects of statins involve improving endothelial function, decreasing vascular inflammation and oxidative stress, and inhibiting the thrombogenic … Webb19 apr. 2010 · This article is part I of a 2-part review, and it focuses on the pleiotropic effects of statins at the cellular level. References. Buhaescu I., Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications . ... Statins: Risk-Benefits and Role in Treating Dyslipidemias.

Webb8 okt. 2015 · Thus, statins may modulate the function of cardiovascular cells and key signalling proteins, including small G-proteins, to ultimately exert their pleiotropic effects. Sphingosine-1-phosphate (S1P) is a naturally occurring bioactive lysophospholipid that regulates diverse physiological functions in a variety of different organ systems. WebbMost pleiotropic effects of statins in cell cultures can be reversed by the addition of mevalonate. Effects that are mediated by Rho GTPases are attributed to the isoprenoid, geranylgeranlpyrophosphate (GGPP). Therefore, increasing mevalonate or GGPP concentrations within extra hepatic cells could limit the benefits of statins.

Webb10 mars 2015 · In summary, statins are probably both under- and over-utilized in older adults. For example, it is estimated that only 40-60% of patients over 65 are prescribed a statin after an acute MI; 24 conversely, a recent study found that 30% of patients with a cancer diagnosis were dispensed a statin within 30 days of dying. 25 For primary … WebbPitavastatin has been shown to have similar pleiotropic effects to other statins, including decreasing platelet activation and improving cardiac and endothelial function. 32 Thus, it …

Webb20 nov. 2024 · While not increasing the risk of bleeding, these pleiotropic antithrombotic effects may contribute to the overall cardiovascular benefits of statins and certain antihypertensive, antiarrhythmic and antidiabetic drugs. Clinicians and scientists may thus want to consider the ancillary effects in their daily practice and research.

Webb6 jan. 2024 · Pleiotropic Effects of Statins on the Cardiovascular System. The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary … grand trail cathareWebb27 okt. 2016 · Individualized Statin Benefit for Determining Statin Eligibility in the Primary Prevention of Cardiovascular Disease. Circulation. 2016 Apr 19;133(16):1574-81. Robinson JG, Ray K. Moving Toward the Next Paradigm for Cardiovascular Prevention. Circulation. 2016 Apr 19;133(16):1533-6. grand trail alsaceWebbStatins exert pleiotropic effects on the cardiovascular system, in part through an increase in nitric oxide (NO) bioavailability. AMP-activated protein kinase (AMPK) plays a central role in controlling energy and metabolism homeostasis in various organs. We therefore studied whether statins can activate AMPK, and if so, whether the activated ... grand trail clermont ferrandWebb15 maj 2024 · Statins also impart a modest benefit in concentrations of triglycerides, high-density lipoproteins (HDL) and very low-density lipoproteins (VLDL). 2 Moreover, statins exert pleiotropic effects such as improvement of endothelial function, enhancing the stability of atherosclerotic plaques, decreasing oxidative stress and inflammation, and … chinese school for kidsWebbför 6 timmar sedan · select article The pleiotropic effects of high-density lipoproteins and apolipoprotein A-I. https: ... select article The advantages and pitfalls of genetic analysis in the diagnosis and management of lipid disorders. ... Statins and diabetes: What are the connections? Naveed Sattar. Article 101749 View PDF. chinese school canteenWebbwith cardiac history. How might the increasing use of statins, with pleiotropic effects, including antiinflammatory activity, alter the effects of immunization? With universal recommendations for influenza vaccination for persons > 6 months of age, how will herd or community immunity affect population levels of influenza activity? grand trail camargueWebb1 dec. 2024 · In addition, the synergistic anti-cancer effects of statins, when combined with other (anti-cancer) drugs, will be discussed in this paper. 2. Pleiotropic properties of statins. “Pleiotropy” originates from the Greek words “pleion” (more) and “tropos” (direction/way), meaning “more than one way”. grand trailer sparta