WebNov 28, 2024 · IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by transient up-regulation in response to... WebWe hypothesize that our methodology will enable the efficient identification of IRF-specific and pan-IRF inhibitors that can be used for the treatment of IRF-dependent disorders and malignancies. Introduction In 1988 the first interferon regulatory factor (IRF) was identified and named IRF1 ( 1, 2 ).
Anti-phospho-c-Abl(Tyr272)抗体 - 上海康朗生物科技有限公司
Another transcription factor of the IRF family important for antiviral defenses [6, 18], IRF1, has previously also been implicated with the DNA damage response [26]. We hypothesized that upon genotoxic insult, IRF1 might be a downstream target of the RLR/IRF3 pathway, as reported for virus infection [18], and thereby … See more To investigate the molecular links between DNA damage-induced cell death and innate immune signaling, we used A549 human lung carcinoma cells, as they … See more In order to investigate the contribution of antiviral signaling cascades to the induction of DSB-induced cell death, we compared the impact of the major antiviral … See more Above we have shown that RLR/IRF3 signaling as well as expression of IRF1 are important for DNA damage-induced cell death. Furthermore, across all conditions … See more WebMar 29, 2024 · IRF1 and IRF2 also appear to be important in regulating DC subset development— Irf −/− mice show a loss of splenic and epidermal DCs (due to augmented type I IFN signaling) ( 109, 110) whereas Irf1−/− exhibit an increase in pDCs and a decrease in CD8 + DCs in mice, along with an increase of IL-10 and TGF-β ( 111 ). higher english courses
Co-Regulation of Immune Checkpoint PD-L1 with Interferon
WebMar 11, 2024 · IRF1 is phosphorylated by GSK3β. ( A) Sequence conservation of the putative GSK3β phospho-target sequence in different species. The phosphorylated T180 and the … WebApr 19, 2024 · Mutation of Tyr613 on IL-27Rα decreased IL-27-induced STAT1 phosphorylation by 80% but had limited effect on STAT3 phosphorgylation. Strong receptor/STAT coupling by IL-27 initiated a unique gene expression program, which required sustained STAT1 phosphorylation and IRF1 expression and was enriched in classical … WebAug 1, 2024 · A and B: Western blot image of IRF1, phospho-Akt, total Akt, and β-Actin in IRF1-FLAG overexpressed HEK293T (A) or Calu3 (B) cells treated with insulin (100 nM) at the indicated time points. C: Western blot image of IRF1 and β-Actin in HEK293T treated with TNF-α with the indicated concentrations for 24 h. D: Western blot image of IRF1 ... how fast was the mosasaurus