WebMay 4, 2011 · Intriguingly, this biochemical route to the perhydro- as -indacene framework of spinosyn A is the same as that used by synthetic chemists William Roush and co … Weblactone ring is fused with a perhydro-as-indacene moiety.” According to Professor Liu, this type of complex bond re - arrangement of a carbon backbone is most commonly asso - ciat ed with terpene biosynthesis. However, the polyketide rather than isoprene nature of spinosyn A suggested that a new
Enzyme-catalysed [4+2] cycloaddition is a key step in the
WebJun 15, 2016 · SpnF represents the first example characterized in vitro of a stand-alone enzyme solely committed to the catalysis of a [4+2] cycloaddition reaction, and the mode of formation of the complex perhydro-as-indacene moiety in spinosyn A is now fully established. 229 WebSpinosyns are glycosylated polyketide-derived macrolides possessing a perhydro-as-indacene core that is presumably formed via a series of intramolecular cross-bridging reactions. The unusual ... sara michelle booker
Faculty Opinions: Enzyme-catalysed [4+2] cycloaddition is a key …
Webtetracyclic ring system (perhydro-as-indacene), which is glycosylated with an amino sugar (D-forosamine) and tri-O-methylrhamnose at C-17 and C-9 respectively (Kim et al. 2007). This group of macrolides was first dis-covered in 1991 by Herbert A. Kirst and his co-workers in Lilly Research Laboratories, where spinosyns A–D WebJun 15, 2016 · Spynosyn A (14), a polyketide-derived insecticide isolated from Saccharopolyspora spinosa, possesses a 22-membered macrolactone with a perhydro-as-indacene scaffold. 39 Biotransformations of ... WebPerhydro Definition. (organic chemistry, in combination) Describing any saturated compound or radical in which every double bond has been replaced as if by the addition of … sara michal brickman seattle