Irg1 acod1
WebHere, we identify the enzyme cis‐aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fever. Infection of mice with C. burnetii induced expression of several anti‐microbial candidate genes, including Acod1. In macrophages, Acod1 was essential for restricting C. burnetii replication ...
Irg1 acod1
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WebSep 16, 2024 · The pathogenic mechanisms of cardiorenal syndrome type 4 (CRS4) remain unclear. Here, the authors identify IRF1-PGC1α axis-mediated myocardial energy … WebIrg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in...
WebDec 8, 2024 · ACOD1 aconitate decarboxylase 1. ACOD1. aconitate decarboxylase 1. Gene ID: 730249, updated on 22-Sep-2024. Gene type: protein coding. Also known as: CAD; IRG1. See all available tests in GTR for this gene. Go to complete Gene record for ACOD1. Go to Variation Viewer for ACOD1 variants. WebJun 7, 2013 · Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate immunity with a more …
WebOct 23, 2024 · Itaconate levels are reduced in bronchoalveolar lavage, and itaconate-synthesizing cis-aconitate decarboxylase expression (ACOD1) is reduced in AMs from patients with IPF compared with controls. In the murine bleomycin model of pulmonary fibrosis, Acod1−/−mice develop persistent fibrosis, unlike wild-type (WT) littermates. WebMar 15, 2024 · IRG1 encodes an aconitate decarboxylase (ACOD1) that produces the immunomodulatory metabolite itaconate (ITA). In addition to rapid intracellular accumulation, ITA is also secreted from the cell, but whether secreted ITA functions as a signaling molecule is unclear. Here, we identified ITA as an orthosteric agonist of the …
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WebFeb 8, 2024 · Irg1 transcript induction was achieved by adding the histone deacetylase (HDAC) inhibitor valproic acid (VPA) to a histidine-tryptophan-ketoglutarate solution used … daredevil leader of the handWebJun 2, 2024 · Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism birth reduction pressuresWebDec 17, 2024 · ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in response to toll-like receptor (TLR) signaling. The activation of STING1 … daredevil luke cage and jessica jones showsWebFeb 14, 2024 · findings suggest that polymorphisms in the immunoresponsive gene 1 (IRG1) gene are associated with the immune response to hepatitis B vaccination; observed that IRG1 inhibited the HBV life cycle and that IRG1 rs17385627 allele 'A' was more effective than rs17385627 allele 'T' at eliminating HBV in HepG2.2.15 cell daredevil man without fearWebApr 1, 2024 · ACOD1 in sterile inflammatory diseases. In addition to pathogen infections, inflammation can also be triggered by tissue damage and stress, leading to various … birth recovery timeWebJul 15, 2024 · ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in response to toll-like receptor (TLR) signaling. birth reflections bathWebDetroit, Michigan's Local 4 News, headlines, weather, and sports on ClickOnDetroit.com. The latest local Detroit news online from NBC TV's local affiliate in Detroit, Michigan, WDIV - … birthree